N-acetylcysteine in Treatment of Trichotillomania
نویسنده
چکیده
Evidence suggests that abnormalities in the corticostriato-thalamic-cortical circuits are one of the key factors underlying the pathophysiology of OCDR, including trichotillomania. Particularly, orbitofrontal cortex, anterior cingulate and ventromedial striatum hypermetabolism has been linked to OCD (Ahmari et al., 2013). Glutamate is the primary neurotransmitter within the cortico-striatothalamic-cortical circuits and evidence suggests that abnormal glutamate metabolism is manifested in subjects with OCRD (Chakrabarty et al., 2005). Also, high levels of glutamate result in excitotoxicity and oxidative stress
منابع مشابه
N-acetylcysteine in trichotillomania as an alternative treatment option
We aimed to examine trichotillomania (TTM), a rarely seen disorder, and N-acetylcysteine (NAC), an agent used as a treatment option, in the light of literature in the present study. Trichotillomania is the compulsive urge to pull out one’s own hair persistently and leading to noticeable hair loss. Contrary to what is expected, it is a more frequently detected disorder characterized by compulsiv...
متن کاملN-Acetylcysteine, a Glutamate Modulator, in the Treatment of Trichotillomania
Context Trichotillomania is characterized by repetitive hair pulling that causes noticeable hair loss. Data on the pharmacologic treatment of trichotillomania are limited to conflicting studies of serotonergic medications. N-acetylcysteine, an amino acid, seems to restore the extracellular glutamate concentration in the nucleus accumbens and, therefore, offers promise in the reduction of compul...
متن کاملN-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study.
CONTEXT Trichotillomania is characterized by repetitive hair pulling that causes noticeable hair loss. Data on the pharmacologic treatment of trichotillomania are limited to conflicting studies of serotonergic medications. N-acetylcysteine, an amino acid, seems to restore the extracellular glutamate concentration in the nucleus accumbens and, therefore, offers promise in the reduction of compul...
متن کاملTrichotillomania: a good response to treatment with N-acetylcysteine*
Trichotillomania is considered a behavioral disorder and is characterized by the recurring habit of pulling one's hair, resulting in secondary alopecia. It affects 1% of the adult population, and 2 to 4.4% of psychiatric patients meet the diagnostic criteria. It can occur at any age and is more prevalent in adolescents and females. Its occurrence in childhood is not uncommon and tends to have a...
متن کاملTrichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata*
Trichotillomania is a psychodermatologic disorder characterized by uncontrollable urge to pull one's own hair. Differential diagnoses include the most common forms of alopecia such as alopecia areata. It is usually associated with depression and obsessive-compulsive disorder. Trichotillomania treatment standardization is a gap in the medical literature. Recent studies demonstrated the efficacy ...
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تاریخ انتشار 2015